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FISH semen quality test

Testing for sperm with abnormal chromosome endowments

We define the most appropriate technique for each case

Why perform this FISH Semen Quality Test?

A seminal quality test by FISH is a quick and effective test that allows us to find out the levels of sperm with abnormal chromosomal endowments in a semen sample, and to assess whether or not they exceed the limits of normality.

Customised techniques for each case

The result of this study helps us to determine which is the most appropriate assisted reproduction technique to choose.

What is the FISH sperm test?

FISH (Fluorescence in situ Hybridization) in spermatozoa is a cytogenetic technique that allows the genetic material of male gametes in a semen sample to be studied.

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It is a diagnostic test that determines the percentage of sperm with chromosomal alterations. Usually, the FISH semen quality test specifically analyses 5 chromosomes: the sex chromosomes (X and Y) and chromosomes 13, 18 and 21, which are the ones most related to failures in assisted reproduction treatments.

Normal spermatozoa have only one chromosome which, when joined to the egg chromosome, forms a complete individual with no chromosomes surplus or missing.

However, if the FISH sperm quality test shows a high percentage of chromosomally altered sperm, this could result in a higher number of aneuploid embryos, i.e. embryos with a chromosomal abnormality. Consequently, these embryos have a lower implantation capacity, a higher risk of miscarriage and potential live births with altered karyotypes.

When to perform the FISH semen quality test

Tambre recommends the FISH test on spermatozoa:
In couples who have suffered repeated miscarriages or implantation failures.

In males with poor sperm quality: low sperm count (oligozoospermia), low motility (asthenozoospermia), or altered morphology (teratozoospermia) and with altered karyotypes (translocations and polymorphisms).

Previous pregnancy with a chromosomal alteration.
Advanced age.

Treatment options after a pathological FISH test

If the FISH semen quality test indicates a higher proportion of spermatozoa with a chromosomal alteration, we can consider different treatment options:

Preimplantation Genetic Diagnosis (PGD) or Preimplantation Genetic Test to check that the embryo has no abnormalities before being transferred. In IVF, this test allows us to select those embryos that have the correct number of chromosomes and, therefore, have a greater probability of implanting and evolving correctly.

Prenatal diagnosis during gestation to check the health of the foetus.

If the chromosomal alterations are very serious, it may be necessary to use donor sperm. At Tambre we have our own sperm bank which enables us to guarantee an excellent quality semen sample, exceeding the reference values established by the WHO.

Treatment of complex infertility cases

At Tambre we are experts in the diagnosis and treatment of complex infertility cases

Specialists in Advanced Reproductive Medicine

We are pioneers in assisted reproduction in Spain and Europe.

45 years of medical excellence. We design tailor-made treatments.

  • You will have your own gynaecologist and nurse, except for emergencies, and the same medical team will follow your case in depth and attend you from the beginning to the end of the treatment.
  • You will have a consultant from our Specialised Tambre Care team who will support you and answer any question you may have throughout the whole process.
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